CCR1 — C-C motif chemokine receptor 1
CCR1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Tissue-resident memory B B cell maturation | CALHM2, CMTM7, FCRL4, FGD4, GSN, ITGB7, PIK3R6, PLD4 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CD2, CD7, CHI3L2, FGR, GPR18, IL17RE +8 more | |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CEBPB, CHMP2B, CHP1 +22 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | AQP9, BACH1, DAPP1, DUSP6, FYB1, IFI16, JAK2 | View in SCUBA |
| Mucosal-associated invariant T cell | Chemokine Receptor Migration migration & adhesion | CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1, PHF14 +6 more | |
| Neutrophils | IFN-gamma Response Antiviral | CARD16, FFAR2, GBP1, GBP5, IFIT2, IFIT3, IFITM3, IRF1 +4 more |
About the gene
| Synonyms | CD191, CKR-1, CMKBR1, MIP1aR, SCYAR1 |
|---|---|
| Chromosome | 3: 46201711-46208313 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.