ADIPOR1 — Adiponectin receptor 1
ADIPOR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADIPOR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS, ERGIC3 +13 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B, CHP1 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | BIRC3, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLF11, KLHL18 +10 more |
About the gene
| Synonyms | ACDCR1, PAQR1 |
|---|---|
| Chromosome | 1: 202940826-202958572 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.