C1D — C1D nuclear receptor corepressor
C1D belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C1D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Lipid Metabolism Housekeeping | ANXA7, AP2B1, ASNSD1, CAPZA2, ECHDC1, EIF3A, GRSF1, HADHB +3 more | View in SCUBA |
About the gene
| Synonyms | LRP1, Rrp47, SUN-CoR, SUNCOR |
|---|---|
| Chromosome | 2: 68041130-68110948 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor, RNA-binding |
| Biological process | Apoptosis, rRNA processing, Transcription, Transcription regulation |
Function
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.