CAPZA2 — Capping actin protein of muscle Z-line subunit alpha 2

CAPZA2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CAPZA2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Lipid Metabolism Housekeeping	ANXA7, AP2B1, ASNSD1, C1D, ECHDC1, EIF3A, GRSF1, HADHB +3 more	View in SCUBA
Endothelial	EC Inflammatory Activation Inflammation	ARHGAP4, ARHGEF2, ARL15, ATP13A3, CD58, GFOD1, GJA4, HABP4 +12 more	View in SCUBA
Fibroblasts	Actin Cytoskeleton Cytoskeletal	ACTB, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, NDUFS5, PCBP1 +6 more	View in SCUBA
Innate lymphoid cells	ER-Golgi Trafficking Protein processing & ER	ATP2B1, ATP6V1D, CGGBP1, CNOT4, COPS5, CRIPT, CSTB, CWC15 +15 more	View in SCUBA
Macrophages	Glycolytic Metabolism Housekeeping	ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CHMP5, CIAO2A +30 more	View in SCUBA
Pericytes	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP1B3, ATP5PF, CALM1, COX17, COX5A, MRPL33, SRP14, TSPO	View in SCUBA
Smooth muscle cells	Actin Dynamics Housekeeping Housekeeping	C12orf75, CFL1, ELN, ENY2, PPIA, PRDX1, PSMB1, RAB2A +3 more	View in SCUBA

About the gene

Synonyms	CAPPA2, CAPZ
Chromosome	7: 116811070-116922049
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Actin capping, Actin-binding

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.