Lipid Metabolism
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are metabolic/housekeeping enzymes: HADHB (mitochondrial fatty acid beta-oxidation), LYPLA1 (lysophospholipase), ECHDC1 (metabolite repair), ASNSD1, SAR1B (COPII vesicle transport), AP2B1 (clathrin adaptor), EIF3A (translation), CAPZA2 (actin capping). No coherent immune program; uniform low expression across subsets suggests a broad metabolic/housekeeping co-expression module. The fatty acid oxidation and lipid metabolism components dominate.
Genes
ANXA7, AP2B1, ASNSD1, C1D, CAPZA2, ECHDC1, EIF3A, GRSF1, HADHB, LYPLA1, SAR1B, TTC1
Most correlated modules
- Mitochondrial Translation · correlation 0.96
- CD4 Lineage Identity · correlation 0.92
- Immune Regulation · correlation 0.92
- Vesicle Trafficking Signaling · correlation 0.89
- OxPhos & proteasome · correlation 0.89
- T Cell Signaling · correlation 0.87
- Regulatory T cell · correlation 0.87
- Oxidative Phosphorylation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.