ECHDC1 — Ethylmalonyl-CoA decarboxylase 1
ECHDC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECHDC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Lipid Metabolism Housekeeping | ANXA7, AP2B1, ASNSD1, C1D, CAPZA2, EIF3A, GRSF1, HADHB +3 more | View in SCUBA |
About the gene
| Synonyms | dJ351K20.2 |
|---|---|
| Chromosome | 6: 127288712-127343609 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
Function
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)- ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.