CACNA2D3 — Calcium voltage-gated channel auxiliary subunit alpha2delta 3
CACNA2D3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNA2D3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte Activation State Inflammatory | ANKRD28, ANXA1, CD300LB, JAML, LDLR, METTL7A, MYADM, NRG1 | View in SCUBA |
About the gene
| Synonyms | alpha2delta-3, HSA272268 |
|---|---|
| Chromosome | 3: 54122547-55074557 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.