Monocyte Activation State
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
CD300LB is a myeloid inhibitory receptor upregulated on activated monocytes; JAML (junction adhesion molecule-like) mediates monocyte transendothelial migration and activation; MYADM is a myeloid differentiation marker; LDLR mediates lipid uptake in activated monocytes; ANXA1 is an anti-inflammatory glucocorticoid-regulated protein expressed in monocytes; NRG1 is a growth/differentiation factor. Module is upregulated in inflammation and downregulated in remission. Moderate coherence suggests a mixed but related monocyte activation state. CACNA2D3 is less clearly linked.
Genes
ANKRD28, ANXA1, CACNA2D3, CD300LB, JAML, LDLR, METTL7A, MYADM, NRG1
Most correlated modules
- AP-1 Stress Response · correlation 0.74
- Inflammatory Monocyte Activation · correlation 0.61
- NR4A Immediate-Early · correlation 0.61
- Heat Shock Response · correlation 0.59
- Macrophage Innate Activation · correlation 0.46
- AP-1 Inflammatory Activation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.