LDLR — Low density lipoprotein receptor

LDLR belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LDLR's module in each cell type

Cell type	Module	Shares the module with
Endothelial	NF-κB Early Response Inflammation	BCL3, BHLHE40, ICAM1, INSIG1, ITPKC, KLF10, MYADM, RND1 +3 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, KLF10 +3 more	View in SCUBA
Gamma-delta T cells	Cholesterol Biosynthesis Housekeeping	CRIM1, CSF1, HS3ST3B1, MSMO1, MUC12, NDFIP2, REG1A, SQLE +1 more
Goblet cells	Stress Survival Response Stress	EPHA2, ERRFI1, EZR, KLF6, LMNA, MCL1, NEDD9, SQSTM1 +3 more	View in SCUBA
Macrophages	Lipid-Sensing Transcriptional Lipid metabolism	ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more	View in SCUBA
Monocytes	Monocyte Activation State Inflammatory	ANKRD28, ANXA1, CACNA2D3, CD300LB, JAML, METTL7A, MYADM, NRG1	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more
Pericytes	EMT-like Remodeling ECM remodeling	APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, RALGDS, RND1 +2 more	View in SCUBA

About the gene

Synonyms	LDLCQ2
Chromosome	19: 11089462-11133820
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Cholesterol metabolism, Endocytosis, Host-virus interaction, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Function

Binds low density lipoprotein /LDL, the major cholesterol- carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.