CCR3 — C-C motif chemokine receptor 3
CCR3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Freshly infiltrated neutrophils Developmental | DSC2, FSTL4, GABRR2, GRAMD1C, HPGD, ITPK1, KIF27, MAK +3 more |
About the gene
| Synonyms | CC-CKR-3, CD193, CKR3, CMKBR3 |
|---|---|
| Chromosome | 3: 46130890-46266706 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Host-virus interaction |
Function
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.