Freshly infiltrated neutrophils
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
This module combines genes from neuronal (GABRR2), epithelial/cardiac (DSC2), hepatic (SLC22A1), germ cell (MAK), and ciliary (KIF27) contexts with no coherent neutrophil biology. Very low mean expression (0.223) and 13.7% detection rate with uniform distribution across subsets is consistent with ambient RNA from multiple non-neutrophil cell types rather than a true transcriptional program.
Genes
CCR3, DSC2, FSTL4, GABRR2, GRAMD1C, HPGD, ITPK1, KIF27, MAK, MICAL2, SLC22A1, SLC7A7
Most correlated modules
- Immature Granulocyte Progenitor · correlation 0.94
- ER Stress Response · correlation 0.91
- Granulopoiesis Transcriptional · correlation 0.87
- PI3K Migration Signaling · correlation 0.86
- TLR5 Bacterial Sensing · correlation 0.86
- Endocytic Vesicle Trafficking · correlation 0.85
- Mature Neutrophil Identity · correlation 0.83
- TLR2 Innate Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.