GRAMD1C — GRAM domain containing 1C
GRAMD1C belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRAMD1C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature enterocyte differentiation Absorption | ABCC2, ACSF2, AOC1, CDC14A, CEP350, EEPD1, EPS8L2, MXI1 +5 more | View in SCUBA |
| Neutrophils | Freshly infiltrated neutrophils Developmental | CCR3, DSC2, FSTL4, GABRR2, HPGD, ITPK1, KIF27, MAK +3 more |
About the gene
| Synonyms | DKFZp434C0328 |
|---|---|
| Chromosome | 3: 113828182-113947174 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Lipid transport, Transport |
Function
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol- binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.