HPGD — 15-hydroxyprostaglandin dehydrogenase
HPGD belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HPGD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CD34+ Quiescent Fibroblast ECM production | ABLIM1, C1QTNF3, CD34, CILP, CLDN11, CPVL, FAIM2, FOLH1 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Basophil Granulocyte development | ENPP3, IL1RL1, ITGB8, KRT1, NDFIP2, SLC18A2, TPSB2, TPSD1 +1 more | |
| Neutrophils | Freshly infiltrated neutrophils Developmental | CCR3, DSC2, FSTL4, GABRR2, GRAMD1C, ITPK1, KIF27, MAK +3 more |
About the gene
| Synonyms | SDR36C1 |
|---|---|
| Chromosome | 4: 174490175-174523154 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid metabolism, Lipid metabolism, Prostaglandin metabolism |
Function
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro- proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.