MAK — Male germ cell associated kinase
MAK belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Freshly infiltrated neutrophils Developmental | CCR3, DSC2, FSTL4, GABRR2, GRAMD1C, HPGD, ITPK1, KIF27 +3 more |
About the gene
| Synonyms | dJ417M14.2, RP62 |
|---|---|
| Chromosome | 6: 10762723-10838553 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Function
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.