CD28 — CD28 molecule
CD28 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD28's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CREBRF, DDX27, ERBIN, ICOS +10 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD40LG, CD82, CNN2, CPNE2, CYB561 +19 more |
About the gene
| Chromosome | 2: 203706475-203738912 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.