CCR2 — C-C motif chemokine receptor 2
CCR2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CD27, CD28, CD40LG, CD82, CNN2, CPNE2, CYB561 +19 more | |
| Hematopoietic progenitor cells | Myeloid Innate Immune Myeloid development | CUX2, CYBB, FXYD7, KCNC3, KIF17, NFKB1, PLD4, RNASE6 +5 more | |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | GAPT, LYST, MAP3K1, MNDA, POU2F2, RGS18, SLC24A4, TMEM154 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chemokine Receptor Migration migration & adhesion | CCR1, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1, PHF14 +6 more |
About the gene
| Synonyms | CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R |
|---|---|
| Chromosome | 3: 46353864-46360940 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Host-virus interaction, Inflammatory response |
Function
Key functional receptor for CCL2 but can also bind CCL7, and CCL12. Also transduces signaling mediated by CCL13. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.