ARL14EP — ADP ribosylation factor like GTPase 14 effector protein
ARL14EP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARL14EP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | AKT survival signaling TCR/AP1/NFKb pathway | ABHD2, AKT1, ATF7, ATP6AP1, CHD8, GNGT2, IP6K2, ITSN2 +10 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2, CYB561 +19 more | |
| Innate lymphoid cells | Endosomal Trafficking Protein processing & ER | CCDC90B, CLINT1, ESF1, MDFIC, MDM4, MPHOSPH8, NRIP1, NSA2 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC, PTP4A2 +8 more |
About the gene
| Synonyms | ARF7EP, C11orf46, FLJ38968 |
|---|---|
| Chromosome | 11: 30323104-30338223 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.