Naïve T Cell State
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 28 genes have a known function matching the annotation |
Why this annotation
The module is tightly coherent (core) and dominated by classical naïve/memory T cell markers. CD27, CD28 are costimulatory receptors defining naïve and early memory T cells; TCF7 (TCF1) is the master transcription factor for naïve and stem-like T cells; CD40LG (CD154) is expressed on activated helper-like T cells; SLAMF1, TNFRSF25 are costimulatory/survival receptors; LTB (lymphotoxin beta) is expressed in lymphoid-homing lymphocytes; GZMK marks early effector/memory T cells; ITGA6 and CCR2 relate to migration; DPP4 (CD26) marks memory T cells. FLT3LG is expressed by T cells and supports dendritic cell development. This cluster collectively defines a naïve-to-early-memory T cell program, consistent with gd T cells retaining naïve/central memory characteristics.
Genes
ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2, CYB561, DPP4, FLT3LG, FUT7, GPR183, GZMK, IGFBP4, ITGA6, LGALS3BP, LTB, LYAR, MCUB, MYC, NOSIP, NPDC1, PACSIN1, RHOU, SLAMF1, TCF7, TNFRSF25
Most correlated modules
- Death Receptor Apoptosis · correlation 0.83
- T Cell Development · correlation 0.83
- γδT17 Effector · correlation 0.67
- Naïve T Cell · correlation 0.61
- TCR Signal Regulation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.