CD27 — CD27 molecule
CD27 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD27's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | IgA plasma cell B cell maturation | AIM2, CORO1B, IGHA1, IGHA2, JCHAIN, MGAT4A, OSBPL10, RASSF6 +2 more | View in SCUBA |
| CD4⁺ T cells | Regulatory T cell Immune regulation | ACTA2, APOLD1, ATP13A3, CARD16, CD79B, DNAH8, FAM184A, HS3ST3B1 +7 more | View in SCUBA |
| CD8⁺ T cells | Effector-Memory CD8 T cell maturation | CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R, HLA-E +8 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD28, CD40LG, CD82, CNN2, CPNE2, CYB561 +19 more |
About the gene
| Synonyms | S152, TNFRSF7, Tp55 |
|---|---|
| Chromosome | 12: 6444955-6451718 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen- specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.