CHCHD3 — Coiled-coil-helix-coiled-coil-helix domain containing 3
CHCHD3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHCHD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1A, ATP5F1C, ATP5MC3, ATP5MG, ATP5PB, ATP5PO, COA3, DBI +21 more | View in SCUBA |
About the gene
| Synonyms | FLJ20420, Mic19, MICOS19, MINOS3, PPP1R22 |
|---|---|
| Chromosome | 7: 132784870-133082090 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.