ATP5PB — ATP synthase peripheral stalk-membrane subunit b
ATP5PB belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP5PB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5MC3, ATP5MF, ATP5PF, COX5A, ELOB, ERH, LDHB, NDUFA12 +8 more | View in SCUBA |
| Gamma-delta T cells | Actin Remodeling Cytoskeletal | AP1M1, APOBEC3C, CAP1, CAPN1, CAPZB, DBNL, LSP1, PIH1D1 +10 more | |
| Goblet cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ATP5F1B, CD99, COTL1, ECHS1, GPR160, HADH, PRDX3, SUCLG1 +1 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, BSG, CCNDBP1 +21 more | View in SCUBA |
| Lymphatic endothelial | Integrin Focal Adhesion migration & adhesion | APLP2, ATP5F1A, DEK, ITGB1, LIMS1, MCFD2, NPC2, NUCKS1 +4 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5, CIAO2A +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis Housekeeping | COPZ1, FERMT3, GPS1, HMGN4, ICAM2, LAMTOR2, LCK, LSM6 +14 more |
About the gene
| Synonyms | ATP5F1 |
|---|---|
| Chromosome | 1: 111448864-111462773 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.