Oxidative Phosphorylation
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 19 of 30 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical oxidative phosphorylation components: ATP5PO, ATP5F1A, ATP5PB, ATP5F1C, ATP5MG (Complex V/ATP synthase), NDUFS3, NDUFB9, NDUFA10, NDUFB6 (Complex I), UQCRC2, UQCRFS1 (Complex III), MTCH2 (mitochondrial carrier). TCA cycle enzymes PDHB, SUCLG1, MDH1, FH are also present. MRPL35 (mitochondrial ribosome) and CHCHD3 (inner membrane) support mitochondrial identity. Core coherence with all genes as core members. Significantly downregulated in both UC and CD inflammation, restored with CD treatment — classic colonocyte metabolic suppression in IBD. This is the most canonical OxPhos module in the batch.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.95
- Oxidative Phosphorylation · correlation 0.93
- Mitochondrial Peroxisomal Metabolism · correlation 0.92
- Mitochondrial Translation · correlation 0.92
- Oxidative Phosphorylation · correlation 0.91
- Mitochondrial Ribosome · correlation 0.90
- Mitochondrial Biogenesis · correlation 0.85
- Colonocyte HOX Identity · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.