DBI — Diazepam binding inhibitor, acyl-CoA binding protein

DBI belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DBI's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1 +14 more	View in SCUBA
CD4⁺ T cells	OxPhos & proteasome Mitochondrial & OxPhos	CCDC167, CLTA, COX17, COX5A, FKBP1A, FMNL1, GALM, MRPL41 +10 more	View in SCUBA
CD8⁺ T cells	Mitochondrial OxPhos Mitochondrial & OxPhos	COX6B1, COX6C, COX7A2, COX7B, ELOB, LSM7, NDUFB2, POMP +5 more	View in SCUBA
Endothelial	ER Protein Processing Protein processing & ER	AP2S1, ATOX1, C1QBP, CCT3, ENO1, NHP2, OSTC, PPIB +5 more	View in SCUBA
Enterocytes	ATP Synthase OXPHOS Mitochondrial & OxPhos	ATP5F1A, ATP5F1B, ATP5MF, ATP5MK, COX4I1, COX7A2, EIF3K	View in SCUBA
Fibroblasts	Proteasome Assembly Housekeeping	ATOX1, C1QBP, DYNLT1, MANF, MRPL52, NDUFV2, PDCD5, PRELID1 +4 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Actin cytotoxicity	ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, MYL12B +14 more
Goblet cells	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP5MC1, ATP5MC3, ATP5PF, MTCH2, NDUFA12, NDUFB2, TPI1	View in SCUBA
Innate lymphoid cells	Proteasome ER Proteostasis Protein processing & ER	ATP5MC1, ATP5PF, GNG5, GTF3C6, HNRNPK, IL4I1, MANF, MED10 +19 more	View in SCUBA
Lymphatic endothelial	20S Proteasome Core Protein processing & ER	ATP6V0E1, CLTA, ERH, NOP10, PRDX1, PSMA7, PSMB1, PSMB2 +4 more	View in SCUBA
Smooth muscle cells	Vascular Tone Signaling Contractility	ADCY3, CPEB4, CYSTM1, EPAS1, EPS8, IER5L, NR2F2, PDE3A +5 more	View in SCUBA

About the gene

Synonyms	ACBD1, ACBP
Chromosome	2: 119366924-119372550
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Biological process	Transport

Function

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.