COA3 — Cytochrome c oxidase assembly factor 3
COA3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA4, COMMD8, GALK1, GEMIN6, ISCA2 +24 more | |
| Innate lymphoid cells | Oxidative Phosphorylation Mitochondrial & OxPhos | APEX1, ATP5F1A, CCNC, DMAC1, ESD, HDAC2, HINT2, LAMTOR1 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER & Mitochondrial Assembly Protein processing & ER | ANAPC11, ARRDC1, ATP5MC1, CSTB, DECR1, GSTK1, HINT2, MRPS26 +9 more |
About the gene
| Synonyms | CCDC56, COX25, hCOA3, HSPC009, MITRAC12 |
|---|---|
| Chromosome | 17: 42795147-42798704 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
Function
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.