CHST7 — Carbohydrate sulfotransferase 7
CHST7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHST7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, DDIT3, DNAAF2, EHD4, FAM43A, ID1 +15 more | |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CDKN1C, CKB, CYFIP2, KNDC1, LYPD2, NEURL1 +6 more | View in SCUBA |
About the gene
| Synonyms | C6ST-2, C6ST2 |
|---|---|
| Chromosome | X: 46573765-46598496 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Carbohydrate metabolism |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.