DDIT3 — DNA damage inducible transcript 3

DDIT3 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DDIT3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Integrated Stress Response Stress	AMD1, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1, PIM2 +4 more	View in SCUBA
CD4⁺ T cells	Integrated Stress Response Stress	CYCS, EIF1, EIF4A3, GTF2B, IFRD1, NASP, PTMA, TUBA1A	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CD83, CDKN1A, ICAM4, IRF1, KDM6B +3 more	View in SCUBA
Gamma-delta T cells	TGF-beta Response Immune regulation	ADGRE5, CD83, CHMP1B, CHST7, DNAAF2, EHD4, FAM43A, ID1 +15 more
Glial cells	Integrated Stress Response Stress	ANKRD37, BAG3, CDKN1A, CSRNP1, EGR2, EGR3, MCL1, MIDN +3 more	View in SCUBA
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT4, GLS, ID1, IFRD1, INTS6, JMJD6, KLF4 +9 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	ATF3, CSRNP1, DNAJA1, EIF4A2, HSP90AB1, PPP1R15A, RSRC2, SERTAD1 +2 more	View in SCUBA
Macrophages	Integrated Stress Response Stress	AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDX39B, EMD, GPS2 +17 more	View in SCUBA
Monocytes	ER Stress Response Stress	CDKN1B, CFAP20, GIMAP5, HSPA5, KLF2, KLF4, ODC1, RHOB +2 more	View in SCUBA
Mucosal-associated invariant T cell	ER Stress UPR Stress	DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA, MAP1LC3B +9 more
Natural Killer cells	Autophagy-Inflammation Stress Stress	BCL2A1, ICAM1, IFFO2, JMJD6, KLF10, MAP1LC3B, MKNK2, SIK3 +3 more	View in SCUBA
Neutrophils	Chemokine Secretion Cytokine & chemokine secretion	CXCL1, CXCL2, CXCL8, GADD45B, GLUL, HCAR2, IER5, MAFF +3 more
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, EGR3, GDF11, HEXIM1, IER5 +4 more	View in SCUBA

About the gene

Synonyms	CHOP, CHOP10, GADD153
Chromosome	12: 57516588-57521737
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding, Repressor
Biological process	Apoptosis, Cell cycle, Growth arrest, Stress response, Transcription, Transcription regulation, Unfolded protein response, Wnt signaling pathway

Function

Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.