EHD4 — EH domain containing 4
EHD4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EHD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell activation TCR/AP1/NFKb pathway | ANKS1B, ARF6, CCT6A, HNRNPM, IRF4, MAP2K3, PFDN2, TRIB1 +3 more | View in SCUBA |
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, DOCK4, EVA1B, EXOC3L2, HDAC7, ITGA6, MCF2L +8 more | View in SCUBA |
| Enterocytes | NF-kB epithelial activation Inflammation | BNIP5, CCL20, HPS5, IL6ST, NFKBIA, RAB8B, RAP1B, TMPRSS2 +1 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, FAM43A, ID1 +15 more | |
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | ARFIP1, BCL2L1, CDS2, CLPB, GNB4, HAVCR2, IVNS1ABP, MINDY2 +9 more | View in SCUBA |
| Pericytes | Pericyte Contractile Tone Cytoskeletal | CARD10, CARD8, FAM110D, IL27RA, KANK3, LDB2, NOSTRIN, PKP4 +4 more | View in SCUBA |
About the gene
| Synonyms | PAST4 |
|---|---|
| Chromosome | 15: 41895933-41972557 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.