TGF-beta Response
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF10 (canonical TGF-beta-inducible transcription factor) and ID1 (BMP/TGF-beta target) anchor this module in TGF-beta signaling. Supporting genes include DDIT3 (stress-activated transcription factor), RGCC (p53/stress-responsive cell cycle regulator), IFRD1 (stress-related developmental regulator), CD83 (early T cell activation marker), RGS16 (G-protein signaling in T cell activation), JMJD6 (epigenetic regulatory response), and LMNA (nuclear remodeling). The uniform expression across subsets and strong coherence support a broadly expressed TGF-beta-driven stress/activation program in gd_T cells rather than subset-specific contamination or a technical artifact.
Genes
ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A, ID1, IFFO2, IFRD1, JMJD6, KLF10, LMNA, N4BP3, NOCT, OSM, PRR7, RALGDS, RARA, RGCC, RGS16, TUBA4A, TUBB2A
Most correlated modules
- Late Activation Autophagy · correlation 0.87
- NF-κB Activation · correlation 0.87
- Heat Stress Apoptotic · correlation 0.86
- ER Proteotoxic Stress · correlation 0.83
- Circadian Clock · correlation 0.83
- TCR Early Activation · correlation 0.79
- Anabolic Activation Response · correlation 0.77
- IFN-gamma Receptor Signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.