CD83 — CD83 molecule

CD83 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CD83's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, DUSP1, EIF1, FOS, FOSB, JUN, JUNB +7 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4, FOSL1 +9 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CDKN1A, DDIT3, ICAM4, IRF1, KDM6B +3 more	View in SCUBA
Gamma-delta T cells	TGF-beta Response Immune regulation	ADGRE5, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A, ID1 +15 more
Glial cells	Inflammatory Activation Response Inflammation	ANGPTL4, C11orf96, CEBPD, ENY2, GEM, IDI1, IRF9, LMO4 +3 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36, PRPF4B +7 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	BCL3, HIF1A, INSIG1, IPO7, IRF1, KDM6B, MAP3K8, NFKBIZ +1 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD, DNAJB6 +33 more	View in SCUBA
Monocytes	Inflammatory Stress Response Stress	ARL5B, ATF3, CCRL2, DUSP10, IL1B, NFE2L2, RASGEF1B, SGK1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CHMP1B, CYCS, DNAAF2, DNAJA1, FOSB +7 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, BIRC3, KDM6B, NFKBID, NR4A1, NR4A3, RASGEF1B, REL	View in SCUBA
Neutrophils	CC Chemokine Secretion Cytokine & chemokine secretion	C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CCRL2, CDKN1A +4 more

About the gene

Synonyms	BL11, HB15
Chromosome	6: 14117256-14136918
Predicted location	Membrane
Essential gene	No
Protein class	CD markers, Predicted membrane proteins

Function

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.