CNOT9 — CCR4-NOT transcription complex subunit 9
CNOT9 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNOT9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | G1/S Transition Cell cycle | ARL6IP6, BTG3, HAT1, HAUS2, PAICS, SFXN1, SLBP, SLC7A1 +1 more | View in SCUBA |
About the gene
| Synonyms | CAF40, CT129, RCD1, RCD1+, RQCD1 |
|---|---|
| Chromosome | 2: 218568580-218597080 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation |
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.