SLBP — Stem-loop binding protein
SLBP belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1 +6 more | View in SCUBA |
| CD8⁺ T cells | Histone Synthesis S-phase Cell cycle | CDK2, EIF4EBP1, HAT1, HNRNPF, HPRT1, PAQR4, RMI2, TMEM109 | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6 +11 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2 +18 more | |
| Hematopoietic progenitor cells | Proteostasis & OxPhos Mitochondrial & OxPhos | COX5A, EIF5A, HNRNPF, HSPA8, ILF2, MRPS34, NDUFB6, PSMB5 | |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | ACADM, AURKAIP1, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1 +19 more | View in SCUBA |
| Macrophages | G1/S Transition Cell cycle | ARL6IP6, BTG3, CNOT9, HAT1, HAUS2, PAICS, SFXN1, SLC7A1 +1 more | View in SCUBA |
About the gene
| Synonyms | HBP |
|---|---|
| Chromosome | 4: 1692731-1712344 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing |
Function
RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.