G1/S Transition
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
TFDP1 encodes DP-1, the obligate E2F dimerization partner driving G1/S transcription. BTG3 is a cell cycle inhibitor acting at G1 checkpoint. SLBP (stem-loop binding protein) processes replication-dependent histone mRNAs specifically in S-phase. HAT1 acetylates newly synthesized histones H4 for deposition during replication. HAUS2 is an augmin subunit for spindle microtubule nucleation. PAICS encodes a bifunctional enzyme in de novo purine biosynthesis, supporting nucleotide pools for DNA replication. SLC7A1 is a cationic amino acid transporter supporting cell growth. SFXN1 transports serine into mitochondria for one-carbon metabolism. This module captures G1/S transition and biosynthetic preparation for DNA replication.
Genes
ARL6IP6, BTG3, CNOT9, HAT1, HAUS2, PAICS, SFXN1, SLBP, SLC7A1, TFDP1
Most correlated modules
- Replication Chromatin Assembly · correlation 0.92
- Centrosome & DNA Repair · correlation 0.92
- DNA Replication Metabolism · correlation 0.88
- Mitotic Spindle Assembly · correlation 0.88
- S-phase DNA Replication · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.