PAICS — Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
PAICS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PAICS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Glycolysis Biosynthesis Mitochondrial & OxPhos | EIF3I, FABP5, LDHA, MDH1, MRPL17, PKM, POLD2, PRDX1 +4 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16 +10 more | View in SCUBA |
| Gamma-delta T cells | Cell Cycle Entry Cell cycle | CDK4, DCTPP1, FH, GGCT, GSS, ISOC2, MBD3, MTHFD1 +4 more | |
| Macrophages | G1/S Transition Cell cycle | ARL6IP6, BTG3, CNOT9, HAT1, HAUS2, SFXN1, SLBP, SLC7A1 +1 more | View in SCUBA |
About the gene
| Synonyms | ADE2H1, AIRC, PAIS |
|---|---|
| Chromosome | 4: 56435741-56464578 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Decarboxylase, Ligase, Lyase, Multifunctional enzyme |
| Biological process | Purine biosynthesis |
Function
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.