SFXN1 — Sideroflexin 1
SFXN1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SFXN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T Cell Signaling B cell help | CCDC6, EFNB2, ELMO1, ETS1, MYO5A, PTPN11, RABGAP1L, SH2D1A +4 more | View in SCUBA |
| Enterocytes | Colonocyte Solute Transport Absorption | ACSS1, ASPA, DAB1, DNASE1, MAOB, SLC26A2, SLC5A11, SLC5A12 +1 more | View in SCUBA |
| Macrophages | G1/S Transition Cell cycle | ARL6IP6, BTG3, CNOT9, HAT1, HAUS2, PAICS, SLBP, SLC7A1 +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ12876, SLC56A1 |
|---|---|
| Chromosome | 5: 175477062-175529742 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, One-carbon metabolism, Transport |
Function
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.