COL8A2 — Collagen type VIII alpha 2 chain
COL8A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL8A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, LIMCH1, MGAT4A, MGAT5, MMP11, MYO7A, NCALD +3 more | View in SCUBA |
About the gene
| Synonyms | FECD, FECD1, PPCD, PPCD2 |
|---|---|
| Chromosome | 1: 36095239-36125222 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Cell adhesion |
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.