MYO7A — Myosin VIIA
MYO7A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYO7A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin adhesion migration & adhesion | ATP11B, CD84, CEP85L, CYTH1, HTRA1, ITGAL, PCNX2, PDE4DIP +4 more | View in SCUBA |
| CD8⁺ T cells | Gut Residence Trm Gut residence | CD96, FUT8, ITGAE, METTL8, NAB1, NAP1L4, PAG1, RAB27A +4 more | View in SCUBA |
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, COL8A2, LIMCH1, MGAT4A, MGAT5, MMP11, NCALD +3 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Lysosomal & pahgocytosis | AP2A2, BLVRB, CD163, FAH, FCGRT, HTRA1, MKKS, RNASE1 +6 more | View in SCUBA |
About the gene
| Synonyms | DFNA11, DFNB2, NSRD2, USH1B |
|---|---|
| Chromosome | 11: 77128246-77215241 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
| Biological process | Hearing |
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.