CHST11 — Carbohydrate sulfotransferase 11
CHST11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHST11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ACP5, B2M, CALCOCO1, CCNG2, CORO1A, HLA-A, IL32, PITPNM2 +10 more | View in SCUBA |
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, COL8A2, LIMCH1, MGAT4A, MGAT5, MMP11, MYO7A, NCALD +3 more | View in SCUBA |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CNST, DCTN4, FBXL20 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | HDAC9, MGAT5, NCAM1, NCOA2, PITPNC1, RASA2, SSH2 |
About the gene
| Synonyms | C4ST, C4St-1, C4ST1, HSA269537 |
|---|---|
| Chromosome | 12: 104455295-104762014 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Carbohydrate metabolism |
Function
Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.