LIMCH1 — LIM and calponin homology domains 1
LIMCH1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIMCH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, ITPKB, KITLG, MALT1 +4 more | View in SCUBA |
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, COL8A2, MGAT4A, MGAT5, MMP11, MYO7A, NCALD +3 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CERS6, CHST15, DOCK5, EPS15, FRMD4B, FRY, IL7 +4 more | View in SCUBA |
About the gene
| Synonyms | DKFZP686A01247, LIMCH1A, LMO7B |
|---|---|
| Chromosome | 4: 41359607-41700044 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.