MGAT5 — Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
MGAT5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGAT5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, COL8A2, LIMCH1, MGAT4A, MMP11, MYO7A, NCALD +3 more | View in SCUBA |
| Lymphatic endothelial | Actin-based Migration Cytoskeletal | AUTS2, GAS7, NHSL1, PAN3, PCCA, PPP6R3, TRIO, ZFPM2 | View in SCUBA |
| Macrophages | Endosomal Rab Trafficking Vesicular traficking | ABL1, ANKS1A, ARB2A, CAMK1D, CPEB3, DENND4C, DISC1, FBXL17 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | CHST11, HDAC9, NCAM1, NCOA2, PITPNC1, RASA2, SSH2 | |
| Neutrophils | General Homeostatic Regulation Housekeeping | ARID2, EXOC4, FBXL17, LARP4B, MCU, RAD51B, RASA1 |
About the gene
| Synonyms | GNT-V, MGAT5A |
|---|---|
| Chromosome | 2: 134119983-134454621 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2. Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N- glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis. [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N- acetylglucosaminyltransferase A]: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.