ECM Glycan Remodeling
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
MMP11 (stromelysin-3, ECM protease) and PCSK6 (proprotein convertase that activates MMPs and TGF-beta) are top hub genes involved in ECM remodeling. MGAT4A and MGAT5 encode N-acetylglucosaminyltransferases involved in glycan modification of ECM proteins. COL8A2 is a collagen, CHST11 a carbohydrate sulfotransferase modifying proteoglycans, and LIMCH1 is a cytoskeletal/actin-binding protein. Together these suggest a specialized ECM processing and glycan-modification program in fibroblasts. Suppressed during inflammation and restored in remission.
Genes
ATP1B1, CHST11, COL8A2, LIMCH1, MGAT4A, MGAT5, MMP11, MYO7A, NCALD, PCSK6, SHANK2, TSHZ2
Most correlated modules
- Fibroblast Niche Identity · correlation 0.94
- Retinoid Stromal Quiescence · correlation 0.90
- Myofibroblast Subtype · correlation 0.87
- Adventitial Fibroblast State · correlation 0.81
- WNT-modulating Fibroblast · correlation 0.80
- TGF-beta Response · correlation 0.79
- Heparan Sulfate Remodeling · correlation 0.78
- Metabolic Homeostasis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.