CSF3R — Colony stimulating factor 3 receptor
CSF3R belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSF3R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Granulocyte Commitment Granulocyte development | C16orf74, C1QTNF4, CEACAM4, CEBPA, CLEC11A, CPVL, IGFBP2, IGLL1 +6 more | |
| Monocytes | Granulocytic Differentiation Developmental | GLT1D1, HEBP2, NDUFB9, NRGN, PLP2, PNPLA2, PXN, SMARCD3 +2 more | View in SCUBA |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CLEC7A, CSF2RB, CYTH4, FCGR2A, LY96, SLC11A1, SLC25A37 +1 more |
About the gene
| Synonyms | CD114, GCSFR |
|---|---|
| Chromosome | 1: 36466043-36483278 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Cell adhesion |
Function
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differentiation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.