IGFBP2 — Insulin like growth factor binding protein 2
IGFBP2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IGFBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Fibroblasts | Chemokine-secreting Fibroblasts Inflammatory | CA12, CCBE1, CHI3L2, CPXM2, CXCL13, CXCL5, GAS1, GPM6B +10 more | View in SCUBA |
| Goblet cells | Secreted Antimicrobials Immune function | FAM3D, IFI6, KLK11, KLK12, NBL1, NOXO1, PCSK1, REG1A +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Granulocyte Commitment Granulocyte development | C16orf74, C1QTNF4, CEACAM4, CEBPA, CLEC11A, CPVL, CSF3R, IGLL1 +6 more | |
| Smooth muscle cells | TGFB-Collagen Remodeling ECM remodeling | COL14A1, LASP1, SYTL2, TGFB3, TPM3, VASN, VGLL3 | View in SCUBA |
About the gene
| Synonyms | IBP2 |
|---|---|
| Chromosome | 2: 216632828-216664436 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor binding |
| Biological process | Growth regulation |
Function
Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.