DBN1 — Drebrin 1
DBN1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DBN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ABCE1, ANXA2, CAMKK2, CORO1C, EIF3J, MIF, PPP1R14B, PTP4A2 +3 more | View in SCUBA |
About the gene
| Synonyms | D0S117E |
|---|---|
| Chromosome | 5: 177456608-177474401 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.