EIF3J — Eukaryotic translation initiation factor 3 subunit J
EIF3J belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF3J's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome translation Housekeeping | ADRM1, CD2BP2, CDV3, CST7, EHBP1L1, ENO1, HSBP1, MAPKAPK2 +5 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ABCE1, ANXA2, CAMKK2, CORO1C, DBN1, MIF, PPP1R14B, PTP4A2 +3 more | View in SCUBA |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | BZW1, CBX5, CSNK1A1, DDX21, EIF2S1, ENPP1, FNBP1, HNRNPA3 +11 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF5B, EMC4, EPRS1 +31 more | View in SCUBA |
About the gene
| Synonyms | eIF3-alpha, eIF3-p35, EIF3S1 |
|---|---|
| Chromosome | 15: 44537125-44563029 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor |
| Biological process | Protein biosynthesis |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.