Actin Cytoskeletal Remodeling
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes PPP1R14B (inhibitor of myosin phosphatase, regulates actomyosin), ANXA2 (annexin A2, actin/membrane dynamics), DBN1 (drebrin, F-actin binding), TPM4 (tropomyosin 4, actin filament stabilization), CORO1C (coronin 1C, actin branching), SH3BGRL3 (SH3 domain glutaredoxin-like, cytoskeletal) form a coherent actin cytoskeleton remodeling program. MIF is a pro-inflammatory cytokine. CAMKK2 and PTP4A2 are signaling kinase/phosphatase. ABCE1 (ABC transporter/ribosome recycling) and EIF3J (translation) are peripheral. The strong upregulation in IBD inflammation (delta ~0.36-0.38, highest in this batch) and reversal in remission suggests active cytoskeletal remodeling during endothelial activation in colitis. As a neighbor of M22 and M70, this module represents a distinct cytoskeletal program co-regulated with the mitochondrial/stress modules.
Genes
ABCE1, ANXA2, CAMKK2, CORO1C, DBN1, EIF3J, MIF, PPP1R14B, PTP4A2, RNF7, SH3BGRL3, TPM4
Most correlated modules
- mRNA Splicing Stress · correlation 0.88
- ER Protein Processing · correlation 0.86
- Mitochondrial OxPhos · correlation 0.85
- Mitochondrial OxPhos · correlation 0.85
- ER Calcium Stress · correlation 0.84
- Actin Vesicle Trafficking · correlation 0.83
- Housekeeping Metabolic · correlation 0.83
- Inflammatory EC Activation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.