SCUBA

PPP1R14B — Protein phosphatase 1 regulatory inhibitor subunit 14B

PPP1R14B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPP1R14B's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsCytotoxic effector
Cytotoxicity
ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 moreView in SCUBA
EndothelialActin Cytoskeletal Remodeling
Cytoskeletal
ABCE1, ANXA2, CAMKK2, CORO1C, DBN1, EIF3J, MIF, PTP4A2 +3 moreView in SCUBA
Gamma-delta T cellsGPCR-AKT-MAPK Signaling
TCR Signaling
ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more
Goblet cellsSR Splicing Factors
RNA processing & translation
CLTA, GLRX5, MLEC, NDUFAB1, SRSF2, SRSF9, TRIR, UQCRFS1 +1 moreView in SCUBA
Lymphatic endothelialMHC-I Antigen Presentation
Immune regulation
ATP6V1F, HLA-A, HLA-B, HLA-C, HLA-E, OAZ1, PSMB8, PSME1 +2 moreView in SCUBA
MacrophagesERAD Proteasome
Housekeeping
ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 moreView in SCUBA
MonocytesMyeloid Epigenetic Regulation
Developmental
CYRIA, GPRC5A, H2AC25, MN1, MTHFD1L, PCGF5, PDE2A, RAPH1 +1 moreView in SCUBA
Mucosal-associated invariant T cellPolycomb Repression
DNA/chromatin regulation
BTBD6, CBX4, CD81, CSNK1G2, CTBP1, DUS1L, GNB1, GRK6 +15 more
Natural Killer cellsILC1/NK Cytotoxic
Cytotoxicity
A1BG, CASK, CLDND1, EIF3G, GZMK, ITM2C, KLRB1, NCF1 +4 moreView in SCUBA
Smooth muscle cellsIFN-gamma/NF-kB Response
Inflammation
ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 moreView in SCUBA

About the gene

SynonymsPHI-1, PLCB3N, PNG, SOM172
Chromosome11: 64244479-64246943
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionProtein phosphatase inhibitor

Function

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.