DIO2 — Iodothyronine deiodinase 2
DIO2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DIO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | ASPN, BCHE, CLEC14A, COL6A5, FNDC1, HMCN1, HMCN2, HPSE2 +5 more | View in SCUBA |
About the gene
| Synonyms | SELENOY, SelY, TXDI2 |
|---|---|
| Chromosome | 14: 80197526-80387757 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Thyroid hormones biosynthesis |
Function
Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'- diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'- monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'- triiodothyronamine and 3',5'- diiodothyronamine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.