ASPN — Asporin
ASPN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASPN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | BCHE, CLEC14A, COL6A5, DIO2, FNDC1, HMCN1, HMCN2, HPSE2 +5 more | View in SCUBA |
| Smooth muscle cells | Contractile Tone Regulation Contractility | FAM13C, HAGH, HSPB6, PDE5A, PJA2, PRELP, RGS3, RNF150 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ20129, PLAP-1, SLRR1C |
|---|---|
| Chromosome | 9: 92456205-92482506 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Biomineralization |
Function
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.