HMCN1 — Hemicentin 1
HMCN1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMCN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | ASPN, BCHE, CLEC14A, COL6A5, DIO2, FNDC1, HMCN2, HPSE2 +5 more | View in SCUBA |
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, CALU, DAG1, HMGN1, ITGA2, PTPRZ1, SDC3 +2 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, KAT2B, MAP3K1 +11 more | View in SCUBA |
About the gene
| Synonyms | ARMD1, FBLN6, FIBL-6, FIBL6 |
|---|---|
| Chromosome | 1: 185734391-186190949 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell cycle, Cell division, Sensory transduction, Vision |
Function
Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Plays a role in basement membrane organization (By similarity). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (By similarity). May play a role in the architecture of adhesive and flexible epithelial cell junctions (By similarity). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.