BCHE — Butyrylcholinesterase
BCHE belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCHE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | ASPN, CLEC14A, COL6A5, DIO2, FNDC1, HMCN1, HMCN2, HPSE2 +5 more | View in SCUBA |
| Glial cells | Enteric Glial Homeostasis Housekeeping | APOE, CCND3, COL12A1, ENTPD2, FXYD6, NPDC1, PAQR6, PCSK1N +5 more | View in SCUBA |
| Smooth muscle cells | Telocyte/Fibroblast Contamination Cell contamination | ABI3BP, ADH1B, ASB2, BMP4, C5orf66-AS1, CDCA7L, FENDRR, HPSE2 +5 more | View in SCUBA |
About the gene
| Synonyms | CHE1, CHE2, E1 |
|---|---|
| Chromosome | 3: 165772904-165837462 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Serine esterase |
Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.